Our lab works at the interface of medicine and engineering, with an emphasis on precisely controlling biomaterial functionality and architecture to treat diseases, control cell behavior, or answer fundamental biological questions. In particular, we are focusing on two avenues: synthetic hydrogels with tunable degradation and mechanical properties as a synthetic extracellular matrix analogue for the culture and delivery of cells for regenerative medicine approaches and polymers formed using reversible-addition fragmentation chain transfer polymerization (RAFT), a controlled, living polymerization strategy, designed with drug delivery applications in mind. Our overall hypothesis is that by using bottom-up approaches, we can design 'smart' materials with distinct capabilities, such as controlling cell behavior or overcoming delivery barriers.
Vats, K.; Marsh, G.; Harding, K.; Zampetakis, I.; Waugh, R.E.; Benoit, D.S.W., "Nanoscale Physicochemical Properties of Chain-and Step-Growith Polymerized PEG Hydrogels Affect Cell-Material Interactions," Journal of Biomedical Materials Research Part A, 2017, 105, 4-1112-1122.
Shubin,A.D.; Felong, T.J.; Schulrum. B.E.; Joe. D.S.L.; Ovit, C.E.; Benoit, D.S.W., "Encapsulation of Primary Salivary Gland Cells in Enzymatically Degradable Poly(ethylene glycol) Hydrogels Promotes Acinar Cell Characteristics," ACTABiomaterialia, 2017, 50, 437-449.
Han, S.F.; Proctor, A.R.; Vella, J.B.; Benoit, D.S.W.; Choe, R., "Non-invasive Diffuse Correlation Tomography Reveals Spatial and Temporal Blood Flow Differences in Murine Bone Grafting Approaches," Biomedical Optics Express, 2016, 7, 9-3262-3279.
Newman, M.R.; Benoit, D.S.W., "Local and Targeted Drug Delivery for Boan Regenerations," Current Opinion in Biotechnology, 2016, 40, 125-132.
Zhou, j.Y.; Horev, B.; Hwang, G.; Klein, M.I.; Koo, H.; Danoit, D.S.W., "Characterization and Optimization of pH-Responsive Polymer Naonparticles for Drug Delivery to Oral Biofims," Journal of Materials Chemistry B, 2016, 4, 18-3075-3085.