{"id":110732,"date":"2023-03-17T13:42:34","date_gmt":"2023-03-17T17:42:34","guid":{"rendered":"https:\/\/www.hajim.rochester.edu\/senior-design-day\/?p=110732"},"modified":"2024-03-01T15:55:52","modified_gmt":"2024-03-01T19:55:52","slug":"clustering-analysis-of-hiv-prevention-strategies-on-magnetic-couples-study","status":"publish","type":"post","link":"https:\/\/www.hajim.rochester.edu\/senior-design-day\/clustering-analysis-of-hiv-prevention-strategies-on-magnetic-couples-study\/","title":{"rendered":"Clustering Analysis of HIV Prevention Strategies on Magnetic Couples Study"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\" style=\"font-style:normal;font-weight:400\"><strong>Team<\/strong><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Yuexuan Ban<\/li>\n\n\n\n<li>Lishan Gao<\/li>\n\n\n\n<li>Xubin Lou<\/li>\n\n\n\n<li>Yuwei Shao<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" style=\"font-style:normal;font-weight:400\"><strong>Sponsor<\/strong> <\/h2>\n\n\n\n<p>Professor James M. McMahon<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" style=\"font-style:normal;font-weight:400\"><strong>Introduction<\/strong><\/h2>\n\n\n\n<h3 class=\"has-normal-font-size wp-block-heading\" style=\"font-style:normal;font-weight:400\"><strong>Background<\/strong><\/h3>\n\n\n\n<p>The HIV epidemic continues to be a major health burden in the U.S., with more than 30,000 new HIV diagnoses annually. A majority of heterosexually transmitted cases of HIV occur among intimate HIV&nbsp;sero-different couples, and there are an estimated 200,000 HIV&nbsp;sero-different couples living in the U.S. There is a lack of data and knowledge regarding the factors associated with HIV transmission in this group.<\/p>\n\n\n\n<h3 class=\"has-normal-font-size wp-block-heading\" style=\"font-style:normal;font-weight:400\"><strong>Mission<\/strong><\/h3>\n\n\n\n<p>Our goal is to help clinicians find the main predictors that are associated with HIV prevention methods and examine how the magnetic couples&#8217; prevention strategies change over time.<\/p>\n\n\n\n<h3 class=\"has-normal-font-size wp-block-heading\" style=\"font-style:normal;font-weight:400\"><strong>Data<\/strong><\/h3>\n\n\n\n<p>A couple-level dataset that contains the survey\/biometric data of 185 variables and 1432 records. Each record contains the survey responses for both the HIV-positive and HIV-negative partners in a given wave.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"751\" src=\"https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/1-4-1024x751.png\" alt=\"\" class=\"wp-image-138512\" srcset=\"https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/1-4-1024x751.png 1024w, https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/1-4-300x220.png 300w, https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/1-4-768x563.png 768w, https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/1-4.png 1132w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n\n<h3 class=\"has-normal-font-size wp-block-heading\" style=\"font-style:normal;font-weight:400\"><strong>Method<\/strong><\/h3>\n\n\n\n<p>We first used t-SNE as the dimensionality reduction method, and then we applied K-Means clustering to explore the predictor variables in waves 1&amp;2 and waves 5&amp;6. Then we used\u00a0TukeyHSD\u00a0and\u00a0Mann Whitney\u00a0to check the significance.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" style=\"font-style:normal;font-weight:400\"><strong>Data&nbsp;Preprocessing<\/strong><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Eliminated the KABST outcome variable.<\/li>\n\n\n\n<li>Separated data into waves 1&amp;2 and waves 5&amp;6.<\/li>\n\n\n\n<li>Calculated the mean for non-missing values.<\/li>\n\n\n\n<li>Dropped couples who have missing values in both waves 1&amp;2 or waves 5&amp;6.&nbsp;&nbsp;<\/li>\n\n\n\n<li>Dichotomized the remaining 3 outcome variables:&nbsp;\n<ul class=\"wp-block-list\">\n<li>IF TFV_DP &lt;500 then&nbsp;TFV_DP_d=0, ELSE&nbsp;TFV_DP_d=1;<\/li>\n\n\n\n<li>IF&nbsp;PCT_COND_mean=0 then&nbsp;COND_d=, ELSE&nbsp;CON_d=1;<\/li>\n\n\n\n<li>IF VL_C&lt;200 THEN&nbsp;VL_d=1 ELSE&nbsp;VL_d=0.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" style=\"font-style:normal;font-weight:400\"><strong>Descriptive Analysis<\/strong><\/h2>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"558\" src=\"https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/2-5-1024x558.png\" alt=\"\" class=\"wp-image-138612\" srcset=\"https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/2-5-1024x558.png 1024w, https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/2-5-300x164.png 300w, https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/2-5-768x419.png 768w, https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/2-5-1200x654.png 1200w, https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/2-5.png 1482w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"368\" src=\"https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/3-4-1024x368.png\" alt=\"\" class=\"wp-image-138642\" srcset=\"https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/3-4-1024x368.png 1024w, https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/3-4-300x108.png 300w, https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/3-4-768x276.png 768w, https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/3-4-1536x552.png 1536w, https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/3-4-1200x431.png 1200w, https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/3-4.png 1602w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"372\" src=\"https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/4-1-1024x372.png\" alt=\"\" class=\"wp-image-138652\" srcset=\"https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/4-1-1024x372.png 1024w, https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/4-1-300x109.png 300w, https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/4-1-768x279.png 768w, https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/4-1-1536x559.png 1536w, https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/4-1-1200x437.png 1200w, https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/4-1.png 1600w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n\n<h2 class=\"wp-block-heading\" style=\"font-style:normal;font-weight:400\"><strong>Clustering Model<\/strong><\/h2>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"721\" src=\"https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/5-1024x721.png\" alt=\"\" class=\"wp-image-138692\" srcset=\"https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/5-1024x721.png 1024w, https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/5-300x211.png 300w, https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/5-768x541.png 768w, https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/5.png 1122w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"773\" src=\"https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/6-1024x773.png\" alt=\"\" class=\"wp-image-138702\" srcset=\"https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/6-1024x773.png 1024w, https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/6-300x226.png 300w, https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/6-768x580.png 768w, https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/6.png 1084w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"572\" src=\"https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/7-1024x572.png\" alt=\"\" class=\"wp-image-138732\" srcset=\"https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/7-1024x572.png 1024w, https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/7-300x168.png 300w, https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/7-768x429.png 768w, https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/7-1536x858.png 1536w, https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/7-1200x670.png 1200w, https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/7.png 1712w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n\n<h2 class=\"wp-block-heading\" style=\"font-style:normal;font-weight:400\"><strong>Results<\/strong><\/h2>\n\n\n\n<h3 class=\"has-normal-font-size wp-block-heading\" style=\"font-style:normal;font-weight:400\"><strong>Age<\/strong><\/h3>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"505\" src=\"https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/Screen-Shot-2023-04-27-at-3.21.45-PM-1024x505.png\" alt=\"\" class=\"wp-image-139102\" srcset=\"https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/Screen-Shot-2023-04-27-at-3.21.45-PM-1024x505.png 1024w, https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/Screen-Shot-2023-04-27-at-3.21.45-PM-300x148.png 300w, https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/Screen-Shot-2023-04-27-at-3.21.45-PM-768x379.png 768w, https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/Screen-Shot-2023-04-27-at-3.21.45-PM-1536x757.png 1536w, https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/Screen-Shot-2023-04-27-at-3.21.45-PM-1200x591.png 1200w, https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/Screen-Shot-2023-04-27-at-3.21.45-PM.png 1692w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n\n<p>For waves 1&amp;2, couples who at least use condoms and&nbsp;PrEP&nbsp;medication are older, and couples who do not use condoms or use only condoms are younger.&nbsp;<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"551\" src=\"https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/9-1024x551.png\" alt=\"\" class=\"wp-image-138822\" srcset=\"https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/9-1024x551.png 1024w, https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/9-300x161.png 300w, https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/9-768x413.png 768w, https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/9-1536x826.png 1536w, https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/9-1200x645.png 1200w, https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/9.png 1662w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n\n<p>For waves 5&amp;6, couples who at least use&nbsp;PrEP&nbsp;are older, and couples who do not use condoms or&nbsp;PrEPare younger. Also, couples who do not use condoms or&nbsp;PrEP&nbsp;&nbsp;are younger. Couples who use condoms and viral load, or at least use&nbsp;PrEP, are older.<\/p>\n\n\n\n<h3 class=\"has-normal-font-size wp-block-heading\" style=\"font-style:normal;font-weight:400\"><strong>Sexual Relationship Power&nbsp;<\/strong><\/h3>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"258\" src=\"https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/10-1024x258.png\" alt=\"\" class=\"wp-image-138882\" srcset=\"https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/10-1024x258.png 1024w, https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/10-300x76.png 300w, https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/10-768x193.png 768w, https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/10-1536x387.png 1536w, https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/10-1200x302.png 1200w, https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/10.png 1676w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n\n<p>For HIV-negative partners\u2019 sexual relationship in waves 1&amp;2, couples who do not use condoms will have weaker partner sexual relationship power. Couples who use condoms and viral load or use at least&nbsp;PrEPhave relatively healthier partner sexual relationship.&nbsp;<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"317\" src=\"https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/11-1024x317.png\" alt=\"\" class=\"wp-image-138962\" srcset=\"https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/11-1024x317.png 1024w, https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/11-300x93.png 300w, https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/11-768x238.png 768w, https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/11-1536x476.png 1536w, https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/11-1200x372.png 1200w, https:\/\/www.hajim.rochester.edu\/senior-design-day\/wp-content\/uploads\/2023\/04\/11.png 1686w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n\n<p>For waves 5&amp;6, couples who at least use&nbsp;PrEP&nbsp;would want to maintain a longer relationship with their partner. Couples who use condoms and viral load or use only condoms would have less willingness to maintain their relationship. Care Satisfaction predictor variable: In&nbsp;waves 1&amp;2, couples with a higher care satisfaction about medical providers use&nbsp;PrEP, contrasting with couples who do not use&nbsp;PrEP.&nbsp;In waves 5&amp;6, couples who do not use condoms or&nbsp;PrEP&nbsp;are HIV-negative partners who have lower care satisfaction with medical providers. Couples who at least use&nbsp;PrEP&nbsp;have higher care satisfaction with medical providers.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" style=\"font-style:normal;font-weight:400\"><strong>Conclusion<\/strong> <\/h2>\n\n\n\n<p>This study focused on using unsupervised learning algorithms to examine the main predictors associated with prevention strategies. We used t-SNE as the dimensionality reduction strategy and K-means as the clustering model. Then we utilized the Tukey HSD test and Mann-Whitney Wilcoxon test to analyze the statistical significance that exists between clusters in different wave comparisons. Our study shows that the main predictors in our study have somewhat significant power in determining magnetic heterosexual couples&#8217; choices when choosing prevention strategies. We would want to further invest in the model by performing testing on more crucial predictors.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" style=\"font-style:normal;font-weight:400\"><strong>Acknowledgements<\/strong><\/h2>\n\n\n\n<p>We&nbsp;want to thank Professor James M. McMahon for the dataset, information, and insights. We also want to thank Professor Ajay Anand and Professor&nbsp;Cantay&nbsp;Caliskan&nbsp;for their support and suggestions on our project.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Magnetic Couple Study collected data and information from heterosexual couples who are of mixed HIV-status and recorded their prevention methods, including condom use, viral load, and new method-PrEP. This project focused on using unsupervised learning algorithms to examine the main predictors associated with protection strategies. <\/p>\n","protected":false},"author":6242,"featured_media":139352,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[106],"tags":[16342,16352,16362],"coauthors":[8612],"class_list":["post-110732","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-dsc-archive","tag-hiv-prevention","tag-prep","tag-urmc-nursing"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Clustering Analysis of HIV Prevention Strategies on Magnetic Couples Study - Senior Design Day<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.hajim.rochester.edu\/senior-design-day\/clustering-analysis-of-hiv-prevention-strategies-on-magnetic-couples-study\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Clustering Analysis of HIV Prevention Strategies on Magnetic Couples Study - Senior Design Day\" \/>\n<meta property=\"og:description\" content=\"Magnetic Couple Study collected data and information from heterosexual couples who are of mixed HIV-status and recorded their prevention methods, including condom use, viral load, and new method-PrEP. 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