"Validations of the Microchannel Flow Model for Characterizing Vascularized Tissues"

November 30, 2020

A paper co-authored by PhD student Sedigheh Poul, postdoctoral associate Dr. Juvenal Ormachea, and Professor Kevin Parker titled "Validations of the microchannel flow model for characterizing vascularized tissues" was published on November 30, 2020 by MDPI journal Fluids. Collaborator Dr. Stefanie Hollenbach (URMC Department of Obstetrics and Gynecology) is also an author. The abstract follows; more information can be found here

Abstract: The microchannel flow model postulates that stress-strain behavior in soft tissues is influenced by the time constants of fluid-filled vessels related to Poiseuille’s law. A consequence of this framework is that changes in fluid viscosity and changes in vessel diameter (through vasoconstriction) have a measurable effect on tissue stiffness. These influences are examined through the theory of the microchannel flow model. Then, the effects of viscosity and vasoconstriction are demonstrated in gelatin phantoms and in perfused tissues, respectively. We find good agreement between theory and experiments using both a simple model made from gelatin and from living, perfused, placental tissue in vitro.