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The Translational Center for Barrier Microphysiological Systems

Publication

Publications

2025

    • Linares, I., Chen, K., Saffren, A., Mansouri, M., Abhyankar, V.V., Miller, B.L., Begolo, S., Awad, H.A., McGrath, J.L., (2025). Fluid flow impacts endothelial-monocyte interactions in a model of vascular inflammatory fibrosis. Scientific Reports. 15:3227. https://doi.org/10.1038/s41598-025-85987-z
    • Ajalik, R.E., Linares, I., Alenchery, R.G., Zhang, V.Z., Wright, T.W., Miller, B.L., McGrath, J.L., Awad, H.A., (2025) Human Tendon‐on‐a‐Chip for Modeling the Myofibroblast Microenvironment in Peritendinous Fibrosis. Advanced Healthcare Materials. 14:2403116. https://doi.org/10.1002/adhm.202403116

 

2024

  • McCloskey, M.C., Ahmad, S.D., Widom, L.P., Kasap, P., Gastfriend, B.D, Shusta, E.V., Palecek, S.P., Engelhardt, B., Gaborski, T.R., Flax, J, Waugh, R.E., McGrath, J.L., (2024) Pericytes enrich the basement membrane and reduce neutrophil transmigration in an in vitro model of peripheral inflammation at the blood brain barrier, Biomaterials Research 28:0081. doi.org/10.34133/bmr.0081
  • Ahmad, S.D., Linares, I., Pietropaoli, A., Waugh, R.E., McGrath J.L. (2024) Sided Stimulation of Endothelial Cells Modulates Neutrophil Trafficking in an in vitro Sepsis Model Advanced Healthcare Materials, 2304338; doi: 10.1002/adhm.202304338
  • Mehran Mansouri, M., Aidan R. Hughes, A.R., Lauren A. Audi, L.A., Anna E. Carter, A.E., Justin A. Vidas, J.A., McGrath, J.L., Abhyankar, V.V., (2024) Transforming Static Barrier Tissue Models into Dynamic Microphysiological Systems, J. Vis. Exp. (204), e66090, doi:10.3791/66090
  • McCloskey, M. C., Kasap, P., Trempel, M., Widom, L. P., Kuebel, J., Chen, K., Gaborski, T. R., Engelhardt, B., McGrath, J. L. (2024) Use of the MicroSiM (µSiM) Barrier Tissue Platform for Modeling the Blood-Brain Barrier. J. Vis. Exp. (203), e65258, doi:10.3791/65258

2023

  • Shargh, A. K. and N. Abdolrahim (2023). “An interpretable deep learning approach for designing nanoporous silicon nitride membranes with tunable mechanical properties.” npj Computational Materials 9. https://www.nature.com/articles/s41524-023-01037-0
  • Soldati, S., A. Bär, M. Vladymyrov, D. Glavin, J. L. McGrath, F. Gosselet, H. Nishihara, S. Goelz and B. Engelhardt (2023). High levels of endothelial ICAM-1 prohibit natalizumab mediated abrogation of CD4+ T cell arrest on the inflamed BBB under flow in vitro. Journal of Neuroinflammation 20(1):123. https://10.1186/s12974-023-02797-8
  • Ahmad, S. D., Cetin, M., Waugh, R. E. & McGrath, J. L. (2023). A computer vision approach for analyzing label free leukocyte trafficking dynamics on a microvascular mimetic. Frontiers in Immunology 14. https://10.3389/fimmu.2023.1140395
  • S. Gholizadeh, D.M. Lincoln, Z. Allahyari, L.P. Widom, R.N. Carter, T.R. Gaborski (2023). Optimization of Parylene C and Parylene N thin films for use in cellular co-culture and tissue barrier models, Scientific Reports 13:4262. https://doi.org/10.1038/s41598-023-31305-4
  • Hudecz, D., McCloskey, M.C., Vergo, S., Christensen, S., McGrath, J.L., Nielsen, M.S. (2023). Modelling a Human Blood-Brain Barrier Co-Culture Using an Ultrathin Silicon Nitride Membrane-Based Microfluidic Device. International Journal of Molecular Sciences 24:5624. https://10.3390/ijms24065624
  • Su, S.H., Song, Y., Stephens, A., Situ, M., McCloskey, M.C., McGrath, J.L., Andjelkovic, A.V., Singer, B.H., and Kurabayashi, K. (2023). A tissue chip with integrated digital immunosensors: In situ brain endothelial barrier cytokine secretion monitoring, Biosensors and Bioelectronics, 224: 115030 https://doi.org/10.1016/j.bios.2022.115030
  • Cognetti, J. S., M. T. Moen, M. G. Brewer, M. R. Bryan, J. D. Tice, J. L. McGrath, and B. L. Miller (2023.) A photonic biosensor-integrated tissue chip platform for real-time sensing of lung epithelial inflammatory markers, Lab Chip. 23: 239-250 https://DOI: 10.1039/d2lc00864e

2022

  • McCloskey, M.C., Zhang, V.Z. Ahmad, S.D., Walker, Romanick, S.S., Awad, H.A., and McGrath, J.L (2022). Sourcing cells for in vitro models of human vascular barriers of inflammation, Frontiers in Medical Technology, 4: 979768. https://doi: 10.3389/fmedt.2022.979768
  • Hsu, M. C., M. Mansouri, N. N. N. Ahamed, S. M. Larson, I. M. Joshi, A. Ahmed, D. A. Borkholder, and V. V. Abhyankar (2022). ‘A miniaturized 3D printed pressure regulator (microPR) for microfluidic cell culture applications’, Sci Rep, 12: 10769. https://doi.org/10.1038/s41598-022-15087-9
  • Mansouri, M., Ahmed, A., Ahmad, D., McCloskey, M.C., Joshi, I.M., Gaborski, T.R., Richard E Waugh, R.E., McGrath, J.L., Day, S.W., Abhyankar V.V (2022). The Modular μSiM Reconfigured: Integration of Microfluidic Capabilities to Study in vitro Barrier Tissue Models Under Flow Advanced Healthcare Materials e2200802 https://doi.org/10.1002/adhm.202200802
  • Ajalik, R.E., Alenchery, R.G., Cognetti, J.S., Zhang, V.Z., McGrath, J.L., Miller, B.L., and Awad, H.A. (2022). Human Organ-on-a-Chip Microphysiological Systems to Model Musculoskeletal Pathologies and Accelerate Therapeutic Discovery, Frontiers in Bioengineering and Biotechnology, 10: 846230
  • McCloskey, M.C., Kasap, P., Ahmad, D.P.S., Su, SH., Chen, K., Mansouri, M. Ramesh, R., Hideaki Nishihara, Belyaev, Y., Abhyankar, V.V., Begolo, S., Singer, B.H., Webb, K.F., Kurabayashi, K., Flax, J., Waugh, R.E., Engelhardt, B., McGrath J.L. (2022). The Modular μSiM: a Mass Produced, Rapidly Assembled, and Reconfigurable Platform for the Study of Barrier Tissue Models In Vitro Advanced Healthcare Materials e2200804 https://doi.org/10.1002/adhm.202200804