Prof. Doyley is an investigator on two University Research Awards
The University of Rochester recently announced the 8 recipients of its University Research Awards (URA). Prof. Doyley is an investigator on two of the projects. University Research Award applications are sought from faculty across the University, and funding is awarded to recipients who demonstrate their projects favor new research with a high probability of being leveraged by future external funding. A review committee of faculty from across the University provides peer review of the applications. Prof. Doyley will be collaborating on the following URA-awarded projects:
PROJECT TITLE: MOLECULAR IMAGING OF ARTERIAL OCCLUSION IN MICE
INVESTIGATORS: Vyacheslav "Slava" A. Korshunov, Associate Professor, Department of Medicine, Aab Cardiovascular Research Institute and Depatment of Biomedical Genetics, School of Medicine & Dentistry; Marvin M. Doyley, Associate Professor, Department of Electrical and Computer Engineering, Hajim School of Engineering & Applied Sciences
GOAL: This research will facilitate high throughput analyses of pathological arterial remodeling in genetically manipulated or pharmacologically treated mice and produce new therapeutic approaches for treating cardiovascular and cerebrovascular diseases. The data generated in this project will be used to support a collaborative NIH research grant (at R01 level) whose goal is to explore the biomechanics of vascular tissues to improve the treatment and diagnosis of cardiovascular diseases. Our findings in mice could produce a diagnostic tool for evaluating pathological arterial remodeling in humans.
PROJECT TITLE: EARLY DETECTION OF CHRONIC KIDNEY DISEASE
INVESTIGATORS: George J. Schwartz, Department of Pediatrics; Marvin M. Doyley, Department of Electrical and Computer Engineering; Jeffrey M. Purkerson, Department of Pediatrics
GOAL: The goal of this project is to understand the pathophysiology of having too much acid in the blood (acidosis) and how it may cause the kidney to become damaged. Such knowledge would encourage clinicians to more readily correct chronic acidosis in children and adults. Our proposed studies will determine whether we can ameliorate some of the kidney damage induced by acidosis. We will also investigate whether acute correction of the acidosis with sodium bicarbonate therapy can reverse the acid-induced increases in kidney stiffness, calcium excretion, and inflammation. These innovative experiments will provide better understanding of the pathophysiology of acidosis and provide the confidence to treat it aggressively early in the setting of chronic kidney disease. Such treatment could slow down the progression of kidney disease and delay the need to initiate dialysis in kidney patients perhaps for many years.
Congratulations to Prof. Doyley and his collaborators!