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Parametric Imaging Research Laboratory

Research

Elastographic Imaging

Elastographic imaging example.Elastography visualizes the biomechanical properties of soft tissues. These properties offer important diagnostic information that clinicians have used to improve the differential diagnosis of breast and prostate cancer, to detect life-threatening plaques in either the carotid or coronary arteries, to improve the diagnosis of non-alcoholic fatty liver disease, and to assess the role the role the mechanical properties in the aging brain. Projects are underway to study how the pancreatic cancer tumor microenvironment responds to immune and anti-stromal therapy. We are also using elastography to investigate vascular aging in patients infected with the HIV virus.


Journal Articles


  1. Combining subharmonic and ultraharmonic modes for intravascular ultrasound imaging: a preliminary evaluation
    Himanshu Shekhar, J. Rowan, and Marvin M. Doyley
    Ultrasound Med Biol 43(11) , pp. 2725 -2732  (2017). View Online
  2. Chirp-coded ultraharmonic imaging with a modified clinical vascular ultrasound system
    Himanshu Shekhar, Steven Huntzicker, I. Awuor, and Marvin M. Doyley
    Ultrason Imaging 38(6) , pp. 403 -419  (2016). View Online
  3. Contrast-enhanced quantitative intravascular elastography: the impact of microvasculature on model-based elastography
    Steven Huntzicker, Himanshu Shekhar, and Marvin M. Doyley
    Ultrasound Med Biol 42(5) , pp. 1167 -1181  (2016). View Online
  4. The delayed onset of subharmonic and ultraharmonic emissions from a phospholipid-shelled microbubble contrast agent
    Himanshu Shekhar, I. Awuor, K. Thomas, J. J. Rychak, and Marvin M. Doyley
    Ultrasound in Medicine and Biology. Vol 40, Issue 4 , pp. 727 -738  (2014). View Online
  5. Modifying the size distribution of microbubble contrast agents for high-frequency subharmonic imaging
    Himanshu Shekhar, J. J. Rychak, and Marvin M. Doyley
    Medical Physics. Vol 40, Issue 5. [Epub ahead of print] (2013). View Online
  6. The response of phospholipid-encapsulated microbubbles to chirp-coded excitation: Implications for high-frequency nonlinear imaging.
    Himanshu Shekhar and Marvin M. Doyley
    Journal of the Acoustical Society of America. Vol 133, Issue 5. [Epub ahead of print] (2013). View Online
  7. Improving the sensitivity of high-frequency subharmonic imaging with coded excitation: A feasibility study.
    Himanshu Shekhar and Marvin M. Doyley
    Medical Physics.39, 2049 (2012); http://dx.doi.org/10.1118/1.3694101. Epub 2012 March 22. (2012). View Online
  8. Parametric subharmonic imaging using a commercial intravascular ultrasound Scanner - an in vivo feasibility study.
    John R. Eisenbrey, Anush Shridharan, Ebo D. deMuinck, Marvin M. Doyley, and Flemming Forsberg
    Journal of Ultrasound in Medicine. March 1, 2012 vol. 31 no. 3. , pp. 361 -371  (2012). View Online