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Parametric Imaging Research Laboratory

Research

Vascular Imaging

Vascular imaging example.Cardiovascular disease represents a major clinical problem both here in the United States and in the rest of the world.  Early detection is challenging because the disease progresses slowly and is, in many cases, asymptomatic.  The goal of this research is to use ultrasound elastography to detect disease in the carotid artery of patients that are at risk of developing cardiovascular disease.  Specifically, we detect vascular aging in the HIV+ population, detect subclinical atherosclerosis, and evaluate the efficacy of novel genetic and pharmacological therapies.


Journal Articles


  1. Senescent phenotype induced by p90RSK-NRF2 signaling sensitizes monocytes and macrophages to oxidative stress in HIV+ individuals: implications for atherogenesis
    M. V. Singh, S. Kotla, N. T. Le, K. A. Ko, K. S. Heo, Y. Wang, Y. Fujii, H. T. Vu, E. McBeath, T. N. Thomas, Y. J. Gi, Y. T. Tao, J. L. Medina, J. Taunton, Nancy Carson, Vikram Dogra, Marvin M. Doyley, A. Tyrell, W. Lu, X. Qiu, N. E. Stirpe, K. Gates, C. Hurley, K. Fujiwara, S. Maggirwar, Giovanni Schifitto, and J. Abe
    Circulation, DOI: 10.1161/CIRCULATIONAHA.118.036232 (2018). View Online
  2. Visualizing angle-independent principal strains in the longitudinal view of the carotid artery: phantom and in vivo evaluation
    Rohit Nayak, Giovanni Schifitto, and Marvin M. Doyley
    Ultrasound Med BIol 44(7) , pp. 1379 -1391  (2018). View Online
  3. Model-based vascular elastography improves the detection of flow-induced carotid artery remodeling in mice
    V. A. Korshunov, H. Wang, R. Ahmed, D. M. Mickelsen, Q. Zhou, C. Yan, and Marvin M. Doyley
    Sci Rep 7 , pp. 12081-1 -12081-12  (2017). View Online
  4. Noninvasive carotid artery elastography using multielement synthetic aperture imaging: phantom and in vivo validation
    Rohit Nayak, Giovanni Schifitto, and Marvin M. Doyley
    Med Phys 44(8) , pp. 4068 -4082  (2017). View Online
  5. Principal strain vascular elastography: simulation and preliminary clinical evaluation
    Rohit Nayak, Steven Huntzicker, Jacques Ohayon, Nancy Carson, Vikram Dogra, Giovanni Schifitto, and Marvin M. Doyley
    Ultrasound Med Biol 43(3) , pp. 682 -699  (2017). View Online
  6. Contrast-enhanced quantitative intravascular elastography: the impact of microvasculature on model-based elastography
    Steven Huntzicker, Himanshu Shekhar, and Marvin M. Doyley
    Ultrasound Med Biol 42(5) , pp. 1167 -1181  (2016). View Online
  7. The imaging modulography technique revisited for high-definition intravascular ultrasound: theoretical framework
    A. Tacheau, Simon Le Floc'h, Gerard Finet, Marvin M. Doyley, Roderic I. Pettigrew, G. Cloutier, and Jacques Ohayon
    Ultrasound Med Biol 42(3) , pp. 727 -741  (2016). View Online
  8. Axl modulates immune activation of smooth muscle cells in vein graft remodeling
    S. Batchu, J. Xia, K. A. Ko, Marvin M. Doyley, J. Abe, C. N. Morrell, and V. A. Korshunov
    Am J Physiol Heart Circ Physiol 309(6) , pp. H1048 -H1058  (2015). View Online
  9. An intravascular coronary plaque elasticity reconstruction method using limited depth penetration ultrasound signals
    A. Tacheau, Simon Le Floc'h, Gerard Finet, Marvin M. Doyley, Roderic I. Pettigrew, G. Cloutier, and Jacques Ohayon
    Comput Methods Biomech Biomed Engin 18(Suppl 1) , pp. 2066 -2067  (2015). View Online
  10. Visualizing the stress distribution within vascular tissues using intravascular ultrasound elastography: a preliminary investigation
    Michael S. Richards, R. Perucchio, and Marvin M. Doyley
    Ultrasound Med Biol 41(6) , pp. 1616 -1631  (2015). View Online
  11. A new finite element method for inverse problems in structural analysis: application to atherosclerotic plaque elasticity reconstruction
    Adeline Bouvier, Flavian Deleaval, Marvin M. Doyley, A. Tacheau, Gerard Finet, Simon Le Floc'h, G. Cloutier, Roderic I. Pettigrew, and Jacques Ohayon
    Comput Methods Biomech Biomed Engin 17(Suppl 1) , pp. 16 -17  (2014). View Online
  12. Quantitative sparse array vascular elastography: the impact of tissue attenuation and modulus contrast on performance
    Steven Huntzicker, Rohit Nayak, and Marvin M. Doyley
    Journal of Medical Imaging. Vol 1, Issue 2 , pp. 027001-1 -027001-13  (2014). View Online
  13. A direct vulnerable atherosclerotic plaque elasticity reconstruction method based on an original material-finite element formulation: theoretical framework
    Adeline Bouvier, Flavian Deleaval, Marvin M. Doyley, Sammi K. Yazdani, Gerard Finet, Simon Le Floc'h, G. Cloutier, Roderic I. Pettigrew, and Jacques Ohayon
    Phys Med Biol 58(23) , pp. 8457 -8476  (2013). View Online
  14. Non-Rigid Image Registration Based Strain Estimator for Intravascular Ultrasound Elastography.
    Michael S. Richards and Marvin M. Doyley
    Ultrasound in Medicine and Biology. Vol 39, Issue 3. [Epub ahead of print] (2013). View Online
  15. Non-invasive Vascular Displacement Estimation for Relative Elastic Modulus Reconstruction in Transversal Imaging Planes.
    Hendrik H. G. Hansen, Michael S. Richards, Marvin M. Doyley, and Chris L. de Korte
    Sensors. Vol 13, Issue 3. [Epub ahead of print] (2013). View Online
  16. Noninvasive Vascular Elastography Using Plane-Wave and Sparse-Array Imaging.
    Sanghamithra Korukonda, Rohit Nayak, Nancy Carson, Giovanni Schifitto, Vikram Dogra, and Marvin M. Doyley
    IEEE Trans. Ultrasonics, Ferroelectrics and Frequency Control. Vol 60, Issue 2. [Epub ahead of print] (2013). View Online
  17. Delineation of Altherosclerotic Plaque Using Subharmonic Imaging Filtering Techniques and a Commercial Intravascular Ultrasound System.
    Anush Shridharan, John R. Eisenbrey, Priscilla Machado, Ebo D. deMuinck, Marvin M. Doyley, and Flemming Forsberg
    Ultrasonic Imaging. Vol 35, Issue 1. [Epub ahead of print] (2013). View Online
  18. Visualizing the Radial and Circumferential Strain Distribution Within Vessel Phantoms Using Synthetic-Aperture Ultrasound Elastography.
    Sanghamithra Korukonda and Marvin M. Doyley
    IEEE Trans. Ultrasonics, Ferroelectrics and Frequency Control. Vol 59, Issue 8. [Epub ahead of print]. (2012). View Online
  19. Investigating the impact of spatial priors on the performance of model-based IVUS elastography.
    Michael S. Richards and Marvin M. Doyley
    Phys Med Biol. 2011 Oct 28;56(22) , pp. 7223 -7246  (2011). View Online
  20. Characterization of atherosclerotic plaques and mural thrombi with intravascular ultrasound elastography: a potential method evaluated in an aortic rabbit model and a human coronary artery.
    R. L. Maurice, J. Fromageau, M. H. R. Cardinal, Marvin M. Doyley, Ebo D. deMuinck, J. Robb, and G. Cloutier
    IEEE Trans. IT in Biomedicine. 12(3). Epub 2008 May 7. , pp. 290 -298  (2008). View Online
  21. Morphological and mechanical information of coronary arteries obtained with intravascular elastography; feasibility study in vivo.
    Chris L. de Korte, S. G. Carlier, F. Mastik, Marvin M. Doyley, A. F. van der Steen, P. W. Serruys, and N. Bom
    Eur Heart J. 23(5) , pp. 405 -413  (2002). View Online
  22. Advancing intravascular ultrasonic palpation toward clinical applications.
    Marvin M. Doyley, F. Mastik, Chris L. de Korte, E. I. C├ęspedes, P. W. Serruys, N. Bom, and A. F. van der Steen
    Ultrasound Med Biol. (11) , pp. 1471 -1480  (2001). View Online