Research
Cancer Imaging
95% of patients with pancreatic cancer die within 5 years of diagnosis. Surgical resection is currently the only treatment option, but only 20% of patients qualify for this surgery. Neoadjuvant chemotherapy can enable patients with borderline resectable tumors to qualify for surgery, but features of the tumor microenvironment (tissue pressure, stromal density, and hyaluronic acid) can reduce its effectiveness. Targeted therapy can mitigate these issues; therefore, the goal of this project is to develop novel surrogate imaging biomarkers for monitoring the effectiveness of neoadjuvant therapies. We use novel imaging techniques to characterize the tumor microenvironment.
Journal Articles
- Shear wave elastography can stratify rectal cancer response to short-course radiation therapy
R. Mislati, T. Uccello, Z. Lin, K. T. Iliza, K. C. Toussaint, S. A. Gerber, and M. M. Doyley
Sci Rep 13(1) , pp. 16149-1 -16149-12 (2023). View Online - Mapping estimates of vascular permeability with a clinical indocyanine green fluorescence imaging system in experimental pancreatic adenocarcinoma tumors
M. S. Reed, M. Ochoa, K. M. Tichauer, A. Weichmann, M. M. Doyley, and B. W. Pogue
J Biomed Opt 28(7) , pp. 076001-1 -076001-14 (2023). View Online - H-scan, shear wave, and bioluminescent assessment of the progression of pancreatic cancer metastases in the liver
J. Baek, R. Ahmed, J. Ye, S. A. Gerber, K. J. Parker, and M. M. Doyley
Ultrasound Med Biol 46(12) , pp. 3369 -3378 (2020). View Online - Parallel receive beamforming improves the performance of focused transmit based single track location shear wave elastography
R. Ahmed and M. M. Doyley
IEEE Trans Ultrason Ferroelectr Freq Control 67(10) , pp. 2057 -2068 (2020). View Online - Preclinical imaging using single track location shear wave elastography: monitoring the progression of murine pancreatic tumor liver metastasis in vivo
R. Ahmed, J. Ye, S. A. Gerber, D. Linehan, and M. M. Doyley
IEEE Trans Med Imaging 39(7) , pp. 2426 -2439 (2020). View Online - Shear wave elastography can differentiate between radiation-responsive and non-responsive pancreatic tumors: an ex vivo study with murine models
H. Wang, B. Mills, R. Mislati, R. Ahmed, S. A. Gerber, D. Linehan, and M. M. Doyley
Ultrasound Med Biol 46(2) , pp. 393 -404 (2020). View Online - Elastography can map the local inverse relationship between shear modulus and drug delivery within the pancreatic ductal adenocarcinoma microenvironment
H. Wang, R. Mislati, R. Ahmed, P. Vincent, S. F. Nwabunwanne, J. Gunn, B. W. Pogue, and M. M. Doyley
Clin Cancer Res 25(7) , pp. 2136 -2143 (2019). View Online - Elastographic assessment of xenograft pancreatic tumors
H. Wang, M. D. Nieskoski, K. Marra, J. Gunn, B. S. Trembly, B. W. Pogue, and M. M. Doyley
Ultrasound Med BIol 43(12) , pp. 2891 -2903 (2017). View Online - Collagen complexity spatially defines micro regions of total tissue pressure in pancreatic cancer
M. D. Nieskoski, K. Marra, J. Gunn, P. J. Hoopes, M. M. Doyley, T. Hasan, B. S. Trembly, and B. W. Pogue
Sci Rep 7 , pp. 10093-1 -10093-12 (2017). View Online - Separation of solid stress from interstitial fluid pressure in pancreas cancer correlates with collagen area fraction
M. D. Nieskoski, K. Marra, J. Gunn, S. C. Kanick, M. M. Doyley, T. Hasan, S. P. Pereira, B. S. Trembly, and B. W. Pogue
J Biomech Eng 139(6) , pp. 061002-1 -061002-8 (2017). View Online - Nanoparticle uptake in tumors is mediated by the interplay of vascular and collagen density with interstitial pressure.
S. Torosean, B. Flynn, J. Axelsson, J. Gunn, K. S. Samkoe, T. Hasan, M. M. Doyley, and B. W. Pogue
Nanomedicine. [Epub ahead of print]. (2012). View Online - Interstitial fluid pressure in soft tissue as a result of an externally applied contact pressure.
A. L. Darling, P. K. Yalavarthy, M. M. Doyley, Hamid Dehghani, and B. W. Pogue
Phys Med Biol. 52(14). Epub 2007 Jun 13. , pp. 4121 -4136 (2007). View Online