Harmonic Imaging

Harmonic imaging example.

Cardiovascular disease represents a major clinical problem both here in the United States and in the rest of the world. Studies have shown that life-threatening plaques usually have abnormal microvasculature. The goal of this project is to develop a contrast-enhanced ultrasound imaging method to detect microvasculature in the carotid and coronary arteries. This includes the development of wideband high frequency ultrasound transducers, and the development of contrast agents for high frequency (> 15 MHz) applications.

Journal Articles

  1. Combining subharmonic and ultraharmonic modes for intravascular ultrasound imaging: a preliminary evaluation
    Himanshu Shekhar, J. Rowan, and M. M. Doyley
    Ultrasound Med Biol 43(11) , pp. 2725 -2732  (2017). View Online
  2. Chirp-coded ultraharmonic imaging with a modified clinical vascular ultrasound system
    Himanshu Shekhar, Steven Huntzicker, I. Awuor, and M. M. Doyley
    Ultrason Imaging 38(6) , pp. 403 -419  (2016). View Online
  3. Contrast-enhanced quantitative intravascular elastography: the impact of microvasculature on model-based elastography
    Steven Huntzicker, Himanshu Shekhar, and M. M. Doyley
    Ultrasound Med Biol 42(5) , pp. 1167 -1181  (2016). View Online
  4. The delayed onset of subharmonic and ultraharmonic emissions from a phospholipid-shelled microbubble contrast agent
    Himanshu Shekhar, I. Awuor, K. Thomas, J. J. Rychak, and M. M. Doyley
    Ultrasound in Medicine and Biology. Vol 40, Issue 4 , pp. 727 -738  (2014). View Online
  5. Modifying the size distribution of microbubble contrast agents for high-frequency subharmonic imaging
    Himanshu Shekhar, J. J. Rychak, and M. M. Doyley
    Medical Physics. Vol 40, Issue 5. [Epub ahead of print] (2013). View Online
  6. The response of phospholipid-encapsulated microbubbles to chirp-coded excitation: Implications for high-frequency nonlinear imaging.
    Himanshu Shekhar and M. M. Doyley
    Journal of the Acoustical Society of America. Vol 133, Issue 5. [Epub ahead of print] (2013). View Online
  7. Improving the sensitivity of high-frequency subharmonic imaging with coded excitation: A feasibility study.
    Himanshu Shekhar and M. M. Doyley
    Medical Physics.39, 2049 (2012); Epub 2012 March 22. (2012). View Online
  8. Parametric subharmonic imaging using a commercial intravascular ultrasound Scanner - an in vivo feasibility study.
    John R. Eisenbrey, Anush Shridharan, Ebo D. deMuinck, M. M. Doyley, and Flemming Forsberg
    Journal of Ultrasound in Medicine. March 1, 2012 vol. 31 no. 3. , pp. 361 -371  (2012). View Online