Prepares Ph.D. students to carry out independent research. Research tools, laboratory skills, experimental methods, critical thinking, presentations, and career planning are discussed as are facilities and resources at UR/URMC.

BUILDING: GRGEN | ROOM: 239

PREREQUISITES: Open ONLY to BME PhD Students

An overview of the theory and practice (with Matlab) of signal processing and analysis with applications to problems in biomedicine. Topics include continuous and discrete time linear systems, Fourier Series and Transforms (1D and 2D), spectral analysis, FIR and IIR digital filters, time-frequency analysis, principle components analysis, Bayes probability, random processes, optimal filters, and fundamentals of digital image processing. Examples drawn from medical applications.

BUILDING: MEL | ROOM: 218

PREREQUISITES: BME230 or ECE241 or permission of instructor.

Molecular biology, biochemistry, and genetics that are required to understand the biomedical and broader biological issue that affect our lives.

BUILDING: HYLAN | ROOM: 101

PREREQUISITES: BIO110 or permission of instructor

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BUILDING: HYLAN | ROOM: 101

Quantitative studies of neural responses at the cellular, circuit, and systems levels. Analytical and computational modeling of neurons and systems, including nonlinear behavior of neurons and neural circuits. Neural coding of information by single cells or neural populations. Introduction to neural networks. Techniques for recording neural activity.

BUILDING: HYLAN | ROOM: 203

PREREQUISITES: Co-requisite: BME260; strong math/computing skill recommended or permission of instructor

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BUILDING: GRGEN | ROOM: 102

This course is designed to provide students with detailed knowledge of the principles of nanotechnology and their applications in the biomedical field. Topics of study will include synthesis & assembly of nanoscale structures, lithography, and nanobiomaterials. Students will focus on biomedically-relevant topics such as cancer treatment, bone disorder, diabetes; and learn how nanotechnology is helping diagnose, treat, and understand these medical disorders. Recent innovative research in the biomedical field will be highlighted during discussions of the latest journal articles. At the end of the course, students will have an appreciation of the enormous potential of biomedical nanotechnology, its current, and future applications

BUILDING: HYLAN | ROOM: 102

PREREQUISITES: BME245

This course introduces students to the theory and practice of control systems engineering. Topics include frequency domain modeling, time domain stability, transient and steady-state error analysis, root locus and frequency response techniques and feedback system design. Emphasis is placed on analyzing physiological control systems, but the concepts and design techniques are applicable and applied to a wide variety of other systems including mechanical and electrical systems. Graduate students will have more homework problems and additional exam problems.

BUILDING: LCHAS | ROOM: 141

PREREQUISITES: Math 163 or 165, ECE 241 or BME 230 (Can be concurrent)

This course will offer students exposure to the intellectual property (IP) and regulatory pathways for new medical innovations. Students will learn the terminology, processes and challenges involved in FDA regulations and the protection of intellectual property for medical innovations. An emphasis will be placed on the ways knowledge of prior art and regulatory barriers can optimize concept selection, and early phase project planning to best identify projects suitable for commercialization. Instruction will include lectures, case studies, guest speakers and integrated assignments that will ask students to explore examples of IP and regulatory challenges, successes and failures. Lectures on regulatory and IP topics will alternate in order to allow students to understand the difficulty presented by balancing these two challenges in the innovation process. Assignments may be tailored to individual students research, design or work concentration areas.

BUILDING: SAUND | ROOM: 1412

This course provides a background in biomaterials: basic material properties, specifics on ceramics, polymers and metals used in the body, and special topics related to biomaterials including tissue engineering, biological responses to implanted materials, and drug delivery.

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PREREQUISITES: CHM131, CHM132, PHY121, PHY122, MTH 161, MTH162, Biomechanics and BIO110 OR permission of instructor

Physics and implementation of X-ray, ultrasonic, and MR imaging systems. Fourier transform relations and reconstruction algorithms of X-ray and ultrasonic-computed tomography, and MRI.

BUILDING: CSB | ROOM: 601

PREREQUISITES: ECE242

This course investigates the imaging techniques applied in state-of-the-art ultrasound imaging and their theoretical bases. Topics include linear acoustic systems, spatial impulse responses, the k-space formulation, methods of acoustic field calculation, dynamic focusing and apodization, scattering, the statistics of acoustic speckle, speckle correlation, compounding techniques, phase aberration correction, velocity estimation, and flow imaging. A strong emphasis is placed on readings of original sources and student assignments and projects based on realistic acoustic simulations.

BUILDING: B&L | ROOM: 269

PREREQUISITES: BME230 or ECE241

This course will focus on the macroscopic biomedical optics techniques (e.g., diffuse optical spectroscopy and tomography, photoacoustic tomography) with high potentials for clinical translation. Students will learn the aspects of instrumentation design, analytic and numerical approaches for optical data analysis, and validation of new technologies in the clinical setting.

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PREREQUISITES: BME221, BME270, OPT241, OPT261

A quantitative, model-oriented approach to physiological systems is presented. Topics include muscle and nerve tissue, the cardiovascular system, the respiratory system, the renal system, and a variety of neural systems

BUILDING: GRGEN | ROOM: 101

PREREQUISITES: ECE 113 or BME 210, or permission of instructor

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BUILDING: GRGEN | ROOM: 104

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BUILDING: GRGEN | ROOM: 104

This course will examine the mechanical properties of cells and the mechanotransduction processes of clinical and technological importance. Topics covered include the role of mechanotransducing biomolecules, models of cell mechanics, and the methods to measure mechanical properties of cells. This course will also introduce students to effects of internal / external mechanical stimuli on cellular processes which may lead to various human diseases. Students will learn basic terminology and concepts of mechanics at the molecular and cellular level with an emphasis on quantitative analysis, modeling, and applications to clinical medicine. Two additional laboratory modules will provide hands-on experience to measure cellular mechanical properties and mechanotransduction signaling using FRET-based force sensors and Calcium dye.

BUILDING: MED | ROOM: 46912

PREREQUISITES: BME 260 (corequisite), BME211/411, BME257, BIO210 or IND431; or permission of instructor

This course will explore the bioprocesses involved in producing a biopharmaceutical product (therapeutic proteins, cell therapy products, and vaccines). The course will take a stepwise journey through a typical production process from the perspective of a Bioprocess Engineer, starting with cell culture and moving downstream through purification and final fill. Engineering concepts involved in bioreactor design and control, cell removal/recovery operations, and protein purification will be examined. The course will also provide an introduction to the analytical methods used to test biopharmaceutical products for critical quality attributes. The role of the regulatory agencies, like the US Food and Drug Administration, and the regulations that govern the industry will be introduced throughout the course in the context of the bioprocess to which they relate. Students taking the course for Upper Level BME or Graduate credit will need to complete a semester-end project.

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PREREQUISITES: BIO110, CHM132, CHE243 OR ME225, CHE244 or Permission of Instructor

In this course, we will survey the role of mechanics in cells, tissues, organs and organisms. A particular emphasis will be placed on the mechanics of the musculoskeletal system, the circulatory system and the eye. Engineering concepts will be used to understand how physical forces contribute to biological processes, especially disease and healing. Experimental and modeling techniques for characterizing the complex mechanical response of biosolids will be discussed in detail, and the continuum mechanics approach will highlighted.

BUILDING: GRGEN | ROOM: 109

PREREQUISITES: ME 226, BME 201 & 201P (or ME 120)

This course provides a thorough grounding on the theory and application of linear steady-state finite element method (FEM) applied to solid mechanics. Topics include: review of matrix algebra and solid mechanics, Principle of Minimum Potential Energy, Rayleigh Ritz Method, FEM computational procedures, isoparametric shape functions and numerical integration for 1D, 2D, and 3D elements, error estimation and convergence, and the demonstration of FEM best practices using a commercial FEM code. A semester project that involves coding FEM software in Matlab is required for graduate students.

BUILDING: HYLAN | ROOM: 105

PREREQUISITES: MTH 164 & MTH 165,ME 226 and ability to program in MATLAB.

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Introduction to topics and devices in the field of neuroengineering. The course will cover approaches to understanding, repairing, replacing, enhancing, and exploiting the properties of neural systems and will include a focus on scientific research directed at the interface between living neural systems and non-living components.

BUILDING: TODD | ROOM: 202

PREREQUISITES: BME210, BME201P, BME230, BME218. Open to Undergraduates with Permission of Instructor.

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BUILDING: GRGEN | ROOM: 101

This course will read and critique journal articles with a primary focus on current research in mechanobiology, including mechanoregulation of stem cell function and mechanisms of mechanotransduction. The philosophy behind this course is that learning is a life-long process that is most effective (and enjoyable!) when independently motivated. Thus, the course is structured to teach critical thinking skills and the ability to independently learn about new research areas from reading scientific literature.

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This course builds on clinical observations and guides the process of selection of an unmet clinical need for further design and development. Teams will refine observed needs, then use brainstorming and prototyping techniques to develop potential concepts. Six Sigma tools will be used to guide design decisions and clarify design requirements. Both oral and written communication skills will be developed.

BUILDING: LCHAS | ROOM: 160

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