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Parker Medical Imaging Research

Tissue Biomechanics and the Microchannel Flow Model

Recent advances have enabled a new wave of biomechanics measurements, and have renewed interest in selecting appropriate rheological models for soft tissues such as the liver, thyroid, and prostate. The microchannel flow model was recently introduced to describe the linear response of tissue to stimuli such as stress relaxation or shear wave propagation. This model postulates a power law relaxation spectrum that results from a branching distribution of vessels and channels in normal soft tissue such as liver. In this work, the derivation is extended to determine the explicit link between the distribution of vessels and the relaxation spectrum. The microchannel flow model explains the dramatic changes in tissue “stiffness” caused by changes in the vasculature, including rapid vasodilation or vasoconstriction.

A microchannel flow model for soft tissue elasticity
K. J. Parker
Phys Med Biol, vol. 59, no. 15, pp. 4443-4457 (2014).  View Online

 


Journal Articles


  1. The biomechanics of simple steatosis and steatohepatitis
    K. J. Parker, J. Ormachea, M. G. Drage, H. Kim, and Z. Hah
    Phys Med Biol, vol. 63, no. 10 , pp. 105013-1 -105013-11  (2018). View PDF
  2. Analysis of transient shear wave in lossy media
    K. J. Parker, J. Ormachea, S. Will, and Z. Hah
    Ultrasound Med Biol, vol. 44, no. 7 , pp. 1504 -1515  (2018). View PDF
  3. Are rapid changes in brain elasticity possible?
    K. J. Parker
    Physics in Medicine and Biology, vol. 62, no. 18 , pp. 7425 -7439  (2017). View Online
  4. The microchannel flow model under shear stress and high frequencies
    K. J. Parker
    Physics in Medicine and Biology, vol. 62, no. 8 , pp. N161 -N167  (2017). View Online
  5. Shear wave dispersion behaviors of soft, vascularized tissues from the microchannel flow, model
    K. J. Parker, J. Ormachea, S. A. McAleavey, R. W. Wood, J. J. Carroll-Nellenback, and R. K. Miller
    Physics in Medicine and Biology, vol. 61, no. 13 , pp. 4890 -4903  (2016). View Online
  6. Biological effects of low frequency strain: physical descriptors
    E. L. Carstensen, K. J. Parker, D. Dalecki, and D. Hocking
    Ultrasound in Medicine and Biology, vol. 42, no. 1 , pp. 1 -15  (2016). View Online
  7. Oestreicher and elastography
    E. L. Carstensen and K. J. Parker
    Journal of the Acoustical Society of America, vol. 138, no. 4 , pp. 2317 -2325  (2015). View PDF
  8. What do we know about shear wave dispersion in normal and steatotic livers?
    K. J. Parker, A. Partin, and D. J. Rubens
    Ultrasound in Medicine and Biology, vol. 41, no. 5 , pp. 1481 -1487  (2015). View Online
  9. Experimental evaluations of the microchannel flow model
    K. J. Parker
    Physics in Medicine and Biology, vol. 60, no. 11 , pp. 4227 -4242  (2015). View Online
  10. Could linear hysteresis contribute to shear wave losses in tissues?
    K. J. Parker
    Ultrasound in Medicine and Biology, vol. 41, no. 4 , pp. 1100 -1104  (2015). View PDF
  11. A microchannel flow model for soft tissue elasticity
    K. J. Parker
    Phys Med Biol, vol. 59, no. 15 , pp. 4443 -4457  (2014). View Online
  12. Real and causal hysteresis elements
    K. J. Parker
    Journal of the Acoustical Society of America, vol. 135, no. 6 , pp. 3381 -3389  (2014). View Online
  13. Physical models of tissue in shear fields
    E. L. Carstensen and K. J. Parker
    Ultrasound in Medicine and Biology, vol. 40, no. 4 , pp. 655 -674  (2014). View Online
  14. The Guassian shear wave in a dispersive medium
    K. J. Parker and N. Baddour
    Ultrasound in Medicine and Biology, vol. 40, no. 4 , pp. 675 -684  (2014). View Online
  15. Congruence of imaging estimators and mechanical measurements of viscoelastic properties of soft tissues
    M. Zhang, B. Castaneda, Z. Wu, P. Nigwekar, J. Joseph, D. J. Rubens, and K. J. Parker
    Ultrasound Med Biol, vol. 33, no. 10 , pp. 1617 -1631  (2007). View PDF