Skip to main content

Research

Biomechanics

finite modelBiomechanics research at the University of Rochester is conducted on multiple levels – from nano-scale molecular interactions between proteins, micro-scale cellular interactions with their extracellular environment, macro-scale mechanics of tissue and systems including joints, circulatory systems among others, all the way up to whole body (organism) dynamics. 

Our research integrates concepts and techniques from a wide range of related fields. For example, our researchers collaborate with molecular biologists or experts in biomedical optics to better understand the responses of cells to their surroundings or mechanical environments. Such research is critical in tissue engineering or the design of cellular interfaces with artificial blood vessels.

Similarly, our orthopaedic biomechanics research often involves the use of advanced medical imaging techniques such as MR or microCT to characterize the mechanical properties of bone and cartilage in healthy or diseased joints.

At both the cellular and macroscopic levels, our research also often involves an integration of experimental and computational methods. For example, students may have an opportunity to create an analytical model of cell migration coupled with the ability to validate their predictions using sophisticated optical imaging techniques.

Similar computational models study the flow of cells within the microvasculature, the function of the meniscus in the knee or the integrity of a healing fracture callus, providing an efficient method to expand the findings of related experimental studies.

At the University of Rochester, our biomechanics research does not stop in the laboratory. Instead, many efforts are underway to translate our findings directly into the clinical setting. 

Example Research Projects:

mechanical testing devicehydrogel culture environmentsbiomechanics2biomechanics3biomechanics4bone repair and regenerationmechanical force and leukocyte adhesion

mechanics of cell cytoplasmcyclic and static loadingfracture healingknee jointknee meniscusknee flexiontargeted drug delivery
local delivery of therapeuticsmicro-fluidics in the inner earmodels of skeletal disease and traumaMR imagingorgan of cortipolymer-drug complexessingle molecule force spectroscopy
tissue engineeringanalysis of children's gaitfemoral condyle achilles tendon


Current Researchers:

Hani A. Awad, PhDMusculoskeletal tissue engineering
Danielle Benoit, PhDTherapeutic biomaterials
Mark Raymond Buckley, PhDViscoelasticity in soft biological tissues; soft tissue aging, disease and repair
Robert L. Clark, PhDDynamic systems, measurement and control, and the exploration of single-molecule mechanics
Sheryl M. Gracewski, PhDGeneral area of solid mechanics
Catherine K. Kuo, PhDTissue engineering; Orthopaedics; Stem cells; Developmental biology; Mechanobiology; Biomaterials
Amy L. Lerner, PhDOrthopaedic biomechanics, bone growth and development, knee biomechanics
Elena Lomakina, PhDCell adhesion, mechanical and thermodynamic properties of biological membranes
James L. McGrath, PhDCell motility, and quantitative light microscopy
Jong-Hoon Nam, PhDBiophysics of inner ear sensory cells, cell mechanics
Renato Perucchio, PhDComputational solid and structural mechanics
J. Edward Puzas, PhDMolecular and cellular biology of the skeletal system
Edward M. Schwarz, PhDPro-inflammatory cytokine signal transduction and novel drug and gene therapies for Rheumatoid Arthritis
Richard E. Waugh, PhDCell adhesion, mechanical and thermodynamic properties of biological membranes; cellular mechanics and function of cytoskeletal proteins
Michael Zuscik, PhDCartilage biology and osteoarthritis