The course deals with computational methods to analytically intractable mathematical problems in biological research. For the first half of the course, general numerical analysis topics are reviewed such as linear algebra, ODE and PDE. Through homework assignments, students write their own computer code. Sufficient sample solutions are given to practice various numerical methods within limited time. The rest of the course is comprised of case studies and projects. Examples of computational analyses are drawn from life science problems such as biodynamics of human loco motion, ion channel kinetics, ionic diffusion, and finite element analysis of cells/tissues. For final project, students bring their own research problems, express them in mathematical equations, solve them using custom written computer programs and interpret the solutions.

BUILDING: GAVET | ROOM: 301

PREREQUISITES: fundamental linear algebra, ordinary differential equation, some experience of Matlab

Viscoelastic materials have the capacity to both store and dissipate energy. As a result, properly describing their mechanical behavior lies outside the scope of both solid mechanics and fluid mechanics. This course will develop constitutive relations and strategies for solving boundary value problems in linear viscoelastic materials. In addition, the closely-related biphasic theory for fluid-filled porous solids will be introduced. An emphasis will be placed on applications to cartilage, tendon, ligament, muscle, blood vessels, and other biological tissues. Advanced topics including non-linear viscoelasticity, composite viscoelasticity and physical mechanisms of viscoelasticity will be surveyed.

BUILDING: HYLAN | ROOM: 101

PREREQUISITES: ME225 or CHE243; ME226 or BME201

This class examines the structure, function, and vulnerability of several major neural systems and how neuroprosthetics may ameliorate damage to them.

BUILDING: MEL | ROOM: 209

PREREQUISITES: Undergraduates allowed with permission of instructor.

The focus of this course is on neural representations of speech sounds; introduction to basics of speech phonetics and responses from the auditory nerve through the brainstem, midbrain, and cortex; techniques for analyzing speech and neural responses. Students from BME, LIN, NSC and other programs will work in interdisciplinary teams on a final project.

BUILDING: B&L | ROOM: 270

PREREQUISITES: BME230 or LIN210/410 or NSC201 or BCS240 or BCS260 or BCS221' or permission of the instructor.

This course introduces students to studies of human brain function using non-invasive methods, including electroencephalography, magnetoencephalography, functional magnetic resonance imaging, electrocorticography. It will focus on experimental paradigms and data analysis in the time and frequency domains. Neural encoding and decoding models and applications to brain-computer interfaces will also be discussed. Course will be a mixed format, with lectures on Tuesdays and labs on (most) Thursdays. Lab exercises will be based around analyzing real data from human subjects.

BUILDING: HYLAN | ROOM: 206

This interactive course focuses on Intellectual Property (IP) and FDA regulatory pathways for medical innovations. Emphasis will be placed on how knowledge of IP protection and evaluation, and regulatory barriers can optimize design, testing and commercialization strategies. Building on BME431 material, students will learn about the processes and barriers to bringing medical products through clinical trials. Instruction will include lectures, case studies, guest speakers and integrated assignments that will ask students to explore examples of IP and regulatory challenges, successes and failures. Lectures on regulatory and IP topics will alternate so students can appreciate the difficulty presented by balancing these two challenges in the innovation process. Some assignments may be tailored to individual students’ research, design or work concentration areas. A project conducted in partnership with the FDA will provide students an opportunity to submit a mock pre-Submission to the FDA for review.

BUILDING: SAUND | ROOM: 1412

This course covers a range of topics in mechanics and biophysics essential to the practice of biomedical engineering at the smallest length scales. The course is taught in two parts. The first half focuses on basic principles such as diffusion and the physical and kinetic properties of biomolecules. This section ends with an integration of these concepts in the study of molecular machines in biology. The second half of the course focuses on microfluidics including basic theory, COMSOL modeling and microfabrication of devices. The course ends with each student building a unique microfluidic system with mentorship from faculty, staff or advanced graduate students. Enrollment is limited.

BUILDING: GRGEN | ROOM: 110

PREREQUISITES: permission of instructor

The course presents the physical basis for the use of high-frequency sound in medicine. Topics include acoustic properties of tissue, sound propagation (both linear and nonlinear) in tissues, interaction of ultrasound with gas bodies (acoustic cavitation and contrast agents), thermal and non-thermal biological effects of utrasound, ultrasonography, dosimetry, hyperthermia and lithotripsy.

BUILDING: B&L | ROOM: 269

PREREQUISITES: Math 163, Math 164, Physics 122 or Permission of instructor

This course analyzes the structural composition of the human body from cellular to organ levels. The goal is to provide a foundation in human anatomy appropriate for students interested in the bioscience and health care professions (e.g. nursing, physical therapy, medicine, bioengineering). Learning objectives will be achieved through a combination of lecture and hands-on (laboratory) approaches, reinforced by clinical examples and analysis of how biomedical devices interface with anatomical structures. In addition, students will participate in small group discussions of clinical case studies, make group presentations of topic appropriate biomedical devices, and prepare a term paper on the subject of their choice selected from a list of topics generated by the instructor.

BUILDING: MED | ROOM: 58526

PREREQUISITES: Any introductory biology course.

This course teaches the principles of modern cell and tissue engineering with a focus on understanding and manipulating the interactions between cells and their environment. After a brief overview of Cell and Tissue Engineering, the course covers 5 areas of the field. These are: 1) Physiology for Tissue Engineering; 2) Bioreactors and Biomolecule Production; 3) Materials for Tissue Engineering; 4) Cell Cultures and Bioreactors and 5) Drug Delivery and Drug Discovery. Within each of these topics the emphasis is on analytical skills and instructors will assume knowledge of chemistry, mass transfer, fluid mechanics, thermodynamics and physiology consistent with the Cell and Tissue Engineering Track in BME. In a term project, students must present written and oral reports on a developing or existing application of Cell and Tissue Engineering. The reports must address the technology behind the application, the clinical need and any ethical implications.

BUILDING: B&L | ROOM: 269

PREREQUISITES: BME 260, CHE225, CHE243 (or ME225), CHE244, BIO210, BIO250, CHM203 or permission of instructor

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BUILDING: GRGEN | ROOM: 230

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BUILDING: GRGEN | ROOM: 230

This course will explore the bioprocesses involved in producing a biopharmaceutical product (therapeutic proteins, cell therapy products, and vaccines). The course will take a stepwise journey through a typical production process from the perspective of a Bioprocess Engineer, starting with cell culture and moving downstream through purification and final fill. Engineering concepts involved in bioreactor design and control, cell removal/recovery operations, and protein purification will be examined. The course will also provide an introduction to the analytical methods used to test biopharmaceutical products for critical quality attributes. The role of the regulatory agencies, like the US Food and Drug Administration, and the regulations that govern the industry will be introduced throughout the course in the context of the bioprocess to which they relate. Students taking the course for Upper Level BME or Graduate credit will need to complete a semester-end project.

BUILDING: HYLAN | ROOM: 201

PREREQUISITES: BIO110, CHM132, CHE243 OR ME225, CHE244 or Permission of Instructor

Course will cover circuits and sensors used to measure physiological systems at an advanced level. Both signal conditioning and sensor characteristics will be addressed. Topics will include measurement of strain, pressure, flow, temperature, biopotentials, and physical circuit construction. The co-requisite laboratory will focus on the practical implementation of electronic devices for biomedical measurements.

BUILDING: LCHAS | ROOM: 160

PREREQUISITES: BME 210, ECE113 or equivalent, or permission of instructor.

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BUILDING: GRGEN | ROOM: 104

This course provides a thorough grounding on the theory and application of linear steady-state finite element method (FEM) applied to solid mechanics. Topics include: review of matrix algebra and solid mechanics, Principle of Minimum Potential Energy, Rayleigh Ritz Method, FEM computational procedures, isoparametric shape functions and numerical integration for 1D, 2D, and 3D elements, error estimation and convergence, and the demonstration of FEM best practices using a commercial FEM code. A semester project that involves coding FEM software in Matlab is required for graduate students.

BUILDING: B&L | ROOM: 269

PREREQUISITES: MTH 164 & MTH 165,ME 226 and ability to program in MATLAB.

This course introduces students to the highly interdisciplinary field of biosensors, with focus on electrochemical transduction. After an overview of the fundamental principles, the course will introduce various strategies to apply the scientific theory and mechanisms to practical issues such as immunoassays, detection of DNA mutation or environmental toxins, metabolic activity, and in-vivo neuronal signal monitoring. The students will be exposed to recent publications that highlight key advances in this field and learn how various chemical, biological and engineering concepts are used in synergy to achieve state-of-the-art sensing of important biological molecules. Emphasis is placed on active participation by students, including literature presentations, critical evaluation of articles, concise technical writing and in-depth discussions.

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PREREQUISITES: Graduate level in materials/chemical engineering (or by approval of instructor).

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BUILDING: GRGEN | ROOM: 101

This course covers the essential aspects of organization and content for writing formal scientific proposals. Open to second-year Ph.D. candidates.

BUILDING: GRGEN | ROOM: 239

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Attend seminars first half of the semester and then students rotate in at least 3 different labs during the first year of graduate study to learn of the diversity of research opportunities for Ph.D. research.

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