Viscoelastic materials have the capacity to both store and dissipate energy. As a result, properly describing their mechanical behavior lies outside the scope of both solid mechanics and fluid mechanics. This course will develop constitutive relations and strategies for solving boundary value problems in linear viscoelastic materials. In addition, the closely-related biphasic theory for fluid-filled porous solids will be introduced. An emphasis will be placed on applications to cartilage, tendon, ligament, muscle, blood vessels, and other biological tissues. Advanced topics including non-linear viscoelasticity, composite viscoelasticity and physical mechanisms of viscoelasticity will be surveyed.

BUILDING: HYLAN | ROOM: 101

PREREQUISITES: ME 225 or CHE 243; and ME 226 or BME 201

This course introduces students to studies of human brain function using non-invasive methods, including electroencephalography, magnetoencephalography, functional magnetic resonance imaging, electrocorticography. It will focus on experimental paradigms and data analysis in the time and frequency domains. Neural encoding and decoding models and applications to brain-computer interfaces will also be discussed. Course will be a mixed format, with lectures on Tuesdays and labs on (most) Thursdays. Lab exercises will be based around analyzing real data from human subjects.

BUILDING: HYLAN | ROOM: 206

PREREQUISITES: BME230 or equivalent class in signals and systems or permission of instructor.

This interactive course focuses on Intellectual Property (IP) and FDA regulatory pathways for new medical innovations. Emphasis will be placed on the ways that knowledge of IP protection and evaluation, and regulatory barriers can optimize design, testing and commercialization strategies. Building on the basics learned in BME431, students will learn about the processes (and barriers) to bringing a product such as a novel medical device through clinical trials. Instruction will include lectures, case studies, guest speakers and integrated assignments that will ask students to explore examples of IP and regulatory challenges, successes and failures. Lectures on regulatory and IP topics will alternate in order to allow students to understand the difficulty presented by balancing these two challenges in the innovation process. Some assignments may be tailored to individual students research, design or work concentration areas and may be reviewed by course instructors as well as consultants.

BUILDING: SAUND | ROOM: 1412

PREREQUISITES: BME431 OR A STRONG REGULATORY AFFAIRS BACKGROUND

This course covers the application of mechanical principles to biotechnology and to understanding life at its smallest scales. Topics will vary with each course offering. Sample topics include force generation by protein polymerization, the mechanisms of bacterial motion, and the separation of biological molecules in porous media.

BUILDING: GRGEN | ROOM: 110

PREREQUISITES: permission of instructor

The course presents the physical basis for the use of high-frequency sound in medicine. Topics include acoustic properties of tissue, sound propagation (both linear and nonlinear) in tissues, interaction of ultrasound with gas bodies (acoustic cavitation and contrast agents), thermal and non-thermal biological effects of utrasound, ultrasonography, dosimetry, hyperthermia and lithotripsy.

BUILDING: B&L | ROOM: 269

PREREQUISITES: MTH 164, MTH 165, PHY 122 or Permission of instructor

This course analyzes the structural composition of the human body from cellular to organ levels. The goal is to provide a foundation in human anatomy appropriate for students interested in the bioscience and health care professions (e.g. nursing, physical therapy, medicine, bioengineering). Learning objectives will be achieved through a combination of lecture and hands-on (laboratory) approaches, reinforced by clinical examples and analysis of how biomedical devices interface with anatomical structures. In addition, students will participate in small group discussions of clinical case studies, make group presentations of topic appropriate biomedical devices, and prepare a term paper on the subject of their choice selected from a list of topics generated by the instructor.

BUILDING: MED | ROOM: 58526

PREREQUISITES: Any introductory biology course.

This course teaches the principles of modern cell and tissue engineering with a focus on understanding and manipulating the interactions between cells and their environment. After a brief overview of Cell and Tissue Engineering, the course covers 5 areas of the field. These are: 1) Physiology for Tissue Engineering; 2) Bioreactors and Biomolecule Production; 3) Materials for Tissue Engineering; 4) Cell Cultures and Bioreactors and 5) Drug Delivery and Drug Discovery. Within each of these topics the emphasis is on analytical skills and instructors will assume knowledge of chemistry, mass transfer, fluid mechanics, thermodynamics and physiology consistent with the Cell and Tissue Engineering Track in BME. In a term project, students must present written and oral reports on a developing or existing application of Cell and Tissue Engineering. The reports must address the technology behind the application, the clinical need and any ethical implications.

BUILDING: GRGEN | ROOM: 109

PREREQUISITES: BME 260, CHE 225 (or ME 123), CHE 243 (or ME 225), CHE 244, BIO210 (or BIO 202 or BME 411), BIO 250, CHM 203 or permission of instructor

This course will explore the bioprocesses involved in producing a biopharmaceutical product (therapeutic proteins, cell therapy products, and vaccines). The course will take a stepwise journey through a typical production process from the perspective of a Bioprocess Engineer, starting with cell culture and moving downstream through purification and final fill. Engineering concepts involved in bioreactor design and control, cell removal/recovery operations, and protein purification will be examined. The course will also provide an introduction to the analytical methods used to test biopharmaceutical products for critical quality attributes The role of the regulatory agencies, like the US Food and Drug Administration, and the regulations that govern the industry will be introduced throughout the course in the context of the bioprocess to which they relate. Graduate students will need to complete a semester-end project in order to receive graduate credit for the course.

BUILDING: HYLAN | ROOM: 201

PREREQUISITES: BIO110, CHM132, CHE243 OR ME225, CHE244

Course will cover circuits and sensors used to measure physiological systems at an advanced level. Both signal conditioning and sensor characteristics will be addressed. Topics will include measurement of strain, pressure, flow, temperature, biopotentials, and physical circuit construction. The co-requisite laboratory will focus on the practical implementation of electronic devices for biomedical measurements.

BUILDING: LCHAS | ROOM: 160

PREREQUISITES: BME 210, ECE113 or equivalent, or permission of instructor.

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BUILDING: GRGEN | ROOM: 104

This course introduces students to the highly interdisciplinary field of biosensors, with focus on electrochemical transduction. After an overview of the fundamental principles, the course will introduce various strategies to apply the scientific theory and mechanisms to practical issues such as immunoassays, detection of DNA mutation or environmental toxins, metabolic activity, and in-vivo neuronal signal monitoring. The students will be exposed to recent publications that highlight key advances in this field and learn how various chemical, biological and engineering concepts are used in synergy to achieve state-of-the-art sensing of important biological molecules. Emphasis is placed on active participation by students, including literature presentations, critical evaluation of articles, concise technical writing and in-depth discussions.

BUILDING: HYLAN | ROOM: 206

PREREQUISITES: Graduate level in materials/chemical engineering (or by approval of instructor).

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BUILDING: GRGEN | ROOM: 101

This course covers the essential aspects of organization and content for writing formal scientific proposals. Open to second-year Ph.D. candidates.

BUILDING: GRGEN | ROOM: 239

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Attend seminars first half of the semester and then students rotate in at least 3 different labs during the first year of graduate study to learn of the diversity of research opportunities for Ph.D. research.

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