The course deals with computational methods to analytically intractable mathematical problems in biological research. For the first half of the course, general numerical analysis topics are reviewed such as linear algebra, ODE and PDE. Through homework assignments, students write their own computer code. Sufficient sample solutions are given to practice various numerical methods within limited time. The rest of the course is comprised of case studies and projects. Examples of computational analyses are drawn from life science problems such as biodynamics of human loco motion, ion channel kinetics, ionic diffusion, and finite element analysis of cells/tissues. For final project, students bring their own research problems, express them in mathematical equations, solve them using custom written computer programs and interpret the solutions.

BUILDING: GAVET | ROOM: 301

PREREQUISITES: Fundamental linear algebra, ordinary differential equation, some experience of Matlab

Viscoelastic materials have the capacity to both store and dissipate energy. As a result, properly describing their mechanical behavior lies outside the scope of both solid mechanics and fluid mechanics. This course will develop constitutive relations and strategies for solving boundary value problems in linear viscoelastic materials. In addition, the closely-related biphasic theory for fluid-filled porous solids will be introduced. An emphasis will be placed on applications to cartilage, tendon, ligament, muscle, blood vessels, and other biological tissues. Advanced topics including non-linear viscoelasticity, composite viscoelasticity and physical mechanisms of viscoelasticity will be surveyed.

BUILDING: HYLAN | ROOM: 101

PREREQUISITES: ME225 or CHE243; ME226 or BME201

This class examines the structure, function, and vulnerability of several major neural systems and how neuroprosthetics may ameliorate damage to them.

BUILDING: MEL | ROOM: 206

PREREQUISITES: Undergraduates allowed with permission of instructor.

The focus of this course is on neural representations of speech sounds; introduction to basics of speech phonetics and responses from the auditory nerve through the brainstem, midbrain, and cortex; techniques for analyzing speech and neural responses. Students from BME, LIN, NSC and other programs will work in interdisciplinary teams on a final project.

BUILDING: B&L | ROOM: 270

PREREQUISITES: BME230 or LIN210/410 or NSC201 or BCS240 or BCS260 or BCS221 or permission of the instructor

This interactive course focuses on Intellectual Property (IP) and FDA regulatory pathways for medical innovations. Emphasis will be placed on how knowledge of IP protection and evaluation, and regulatory barriers can optimize design, testing and commercialization strategies. Building on BME431 material, students will learn about the processes and barriers to bringing medical products through clinical trials. Instruction will include lectures, case studies, guest speakers and integrated assignments that will ask students to explore examples of IP and regulatory challenges, successes and failures. Lectures on regulatory and IP topics will alternate so students can appreciate the difficulty presented by balancing these two challenges in the innovation process. Some assignments may be tailored to individual student's research, design or work concentration areas. A project conducted in partnership with the FDA will provide students an opportunity to submit a mock pre-Submission to the FDA for review and feedback.

BUILDING: SAUND | ROOM: 1412

This course covers a range of topics in mechanics and biophysics essential to the practice of biomedical engineering at the smallest length scales. The course is taught in two parts. The first half focuses on basic principles such as diffusion and the physical and kinetic properties of biomolecules. This section ends with an integration of these concepts in the study of molecular machines in biology. The second half of the course focuses on microfluidics including basic theory, COMSOL modeling and microfabrication of devices. The course ends with each student building a unique microfluidic system with mentorship from faculty, staff or advanced graduate students. Enrollment is limited.

BUILDING: GRGEN | ROOM: 110

PREREQUISITES: permission of instructor

The course presents the physical basis for the use of high-frequency sound in medicine. Topics include acoustic properties of tissue, sound propagation (both linear and nonlinear) in tissues, interaction of ultrasound with gas bodies (acoustic cavitation and contrast agents), thermal and non-thermal biological effects of utrasound, ultrasonography, dosimetry, hyperthermia and lithotripsy.

BUILDING: B&L | ROOM: 269

PREREQUISITES: Math 164, Math 165, Physics 122 or Permission of instructor

This course analyzes the structural composition of the human body from cellular to organ levels. The goal is to provide a foundation in human anatomy appropriate for students interested in the bioscience and health care professions (e.g. nursing, physical therapy, medicine, bioengineering). Learning objectives will be achieved through a combination of lecture and hands-on (laboratory) approaches, reinforced by clinical examples and analysis of how biomedical devices interface with anatomical structures. In addition, students will participate in small group discussions of clinical case studies, make group presentations of topic appropriate biomedical devices, and prepare a term paper on the subject of their choice selected from a list of topics generated by the instructor.

BUILDING: MED | ROOM: 37619

PREREQUISITES: Any introductory biology course.

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BUILDING: MED | ROOM: 46912

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BUILDING: MED | ROOM: 58526

This course teaches the principles of modern cell and tissue engineering with a focus on understanding and manipulating the interactions between cells and their environment. After a brief overview of Cell and Tissue Engineering, the course covers 5 areas of the field. These are: 1) Physiology for Tissue Engineering; 2) Bioreactors and Biomolecule Production; 3) Materials for Tissue Engineering; 4) Cell Cultures and Bioreactors and 5) Drug Delivery and Drug Discovery. Within each of these topics the emphasis is on analytical skills and instructors will assume knowledge of chemistry, mass transfer, fluid mechanics, thermodynamics and physiology consistent with the Cell and Tissue Engineering Track in BME. In a term project, students must present written and oral reports on a developing or existing application of Cell and Tissue Engineering. The reports must address the technology behind the application, the clinical need and any ethical implications.

BUILDING: B&L | ROOM: 270

PREREQUISITES: BME 260, CHE225, CHE243 (or ME225), CHE244, BIO210, BIO250, CHM203 or permission of instructor

This course will introduce students to the principles of protein & DNA structure and function; fundamental principles of protein folding domains, DNA structures, the spatial and conceptual relationships of biomolecules, role of amino acids mutation, and mutation induced abnormal functions, which may be linked directly to human diseases. The course will be taught using multiple instructional methods, including lectures, labs using the open source program Visual Molecular Dynamics (VMD), and oral presentations with an associated critical discussion.

BUILDING: MEL | ROOM: 210

PREREQUISITES: BIO110 or Permission of Instructor

This course introduces the fundamentals of optical microscopy for students with some or limited exposure to biomedical microscopy. Topics will include contemporary applications in biology and medicine with a focus on understanding imaging technologies such as confocal microscopy, two photon imaging, optical coherence tomography, digital microscopy and clinical histopathology.

BUILDING: MEL | ROOM: 209

Course will cover circuits and sensors used to measure physiological systems at an advanced level. Both signal conditioning and sensor characteristics will be addressed. Topics will include measurement of strain, pressure, flow, temperature, biopotentials, and physical circuit construction. The co-requisite laboratory will focus on the practical implementation of electronic devices for biomedical measurements.

BUILDING: LCHAS | ROOM: 103

PREREQUISITES: BME 210, ECE113 or equivalent, or permission of instructor.

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BUILDING: GRGEN | ROOM: 104

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BUILDING: GRGEN | ROOM: 101

This course covers the essential aspects of organization and content for writing formal scientific proposals. Open to second-year Ph.D. candidates.

BUILDING: GRGEN | ROOM: 239

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Attend seminars first half of the semester and then students rotate in at least 3 different labs during the first year of graduate study to learn of the diversity of research opportunities for Ph.D. research.

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