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BME Medical

TKA Infection Control

After a total knee arthroplasty (TKA) surgery, some patients experience infection at the surgical site. This infection is often associated with the formation of bacterial biofilm, and in order to treat this, the surgeon must remove and replace the implant with the risk of reduced mobility and bone fraction. Our project is to develop a medical device to eradicate the biofilm without the necessity to remove the orthopedic implant.

Team Members

Josh Cooley
Michele Counts
Zachary Davis
Yara Izhiman

Supervisors

Dr. Hani Awad

Customers

Dr. Thomas Myers

Description

After a total knee arthroplasty (TKA) surgery, some patients experience infection at the surgical site. This infection is often associated with the formation of bacterial biofilm, and in order to treat this, the surgeon must remove and replace the implant with the risk of reduced mobility and bone fraction. Our project is to develop a medical device to eradicate the biofilm without the necessity to remove the orthopedic implant.

Design of the medical device to be wrapped around the knee.

6 replies on “TKA Infection Control”

I’d be interested in learning more. What is your final use plan for reducing biofilm?

This would certainly be a useful device. How does electricity remove the bacterial biofilm? Congratulations to you all!

Dr. Heinzelman,
Thank you for your comment!
The electrical stimulation is used to disturb and break the baterial biofilm,which is a protective layer of extracellular polymeric substances including polysaccharides, proteins, and extracellular DNA, that is blocking the bacteria underneath from the immune system and antibiotics. So our device is intended to first break this biofilm layer so that antibiotics specific to the bacterial strain can be administered and reach the site to clear the infection.

Hi Dr. Myers,
Thank you for attending our presentation yesterday!
We are putting together our final report and we should get that to you by the end of this week so we can discuss more from there.
If there is something that you wished that we discussed during the presentation but did not, please feel free to let us know so we can address that in the report!

Great to see you have moved this forward wrt electrode position. What kind of voltages do you thing will be necessary?

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